APOE4 Facilitates the Accumulation and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels
Published in Alzheimer's & Dementia, 2023
Recommended citation: Steward, A., Biel, D., Dewenter, A., Roemer, S.N., Wanger, F., Dehsarvi, A., Svaldi, D., Higgins, I.A., Brendel, M., Shcherbinin, S., Ewers, M., Franzmeier, N. (2023). APOE4 Facilitates the Accumulation and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels. Alzheimer's Dement., 19: e074017. https://doi.org/10.1002/alz.074017. https://doi.org/10.1002/alz.074017
This paper investigates how APOEε4 facilitates the accumulation and connectivity-mediated spreading of tau pathology at lower amyloid levels. The findings shed light on the role of APOEε4 in the pathogenesis of Alzheimer’s disease, potentially informing the development of targeted therapeutic strategies.
Recommended citation: Steward, A., Biel, D., Dewenter, A., Roemer, S.N., Wanger, F., Dehsarvi, A., Svaldi, D., Higgins, I.A., Brendel, M., Shcherbinin, S., Ewers, M., Franzmeier, N. (2023). APOEε4 Facilitates the Accumulation and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels. Alzheimer’s Dement., 19: e074017. https://doi.org/10.1002/alz.074017.