Publications

This study demonstrates that the ApoE4 risk allele lowers the threshold of plasma phosphorylated tau 217 (ptau217) required to drive fibrillar tau aggregation and spread in Alzheimer’s disease in a dose-dependent manner.

This study establishes patient-centered amyloid PET thresholds for the onset of tauopathy, demonstrating that age and sex significantly influence the amyloid-to-tauopathy transition in Alzheimer’s disease.

AAIC 2025 conference abstract, published in the Alzheimer's & Dementia supplement.

AAIC 2025 conference abstract, published in the Alzheimer's & Dementia supplement.

AAIC 2025 conference abstract, published in the Alzheimer's & Dementia supplement.

AAIC 2025 conference abstract, published in the Alzheimer's & Dementia supplement.

AAIC 2025 conference abstract, published in the Alzheimer's & Dementia supplement.

AAIC 2025 conference abstract, published in the Alzheimer's & Dementia supplement.

AAIC 2025 conference abstract, published in the Alzheimer's & Dementia supplement.

This systematic study compares longitudinal changes in A/T/N biomarkers (amyloid-PET, tau-PET, plasma p-tau217, and MRI) for tracking cognitive changes in Alzheimer's disease, finding plasma p-tau217 to be a robust, cost-effective alternative to tau-PET.

This study demonstrates that cortical tau accumulation promotes atrophy in connected white matter regions in Alzheimer's disease, highlighting the role of tau-induced axonal degeneration.

This study develops and validates a novel data-driven temporo-orbital white matter reference region for [18F]PI-2620-PET imaging, optimizing the assessment of 4-repeat tauopathies, particularly in Progressive Supranuclear Palsy (PSP).

This study investigates how brain networks influence the patterns of neurodegeneration in patients with Progressive Supranuclear Palsy (PSP).

This study investigates multimodal spatial gradients to explain regional susceptibility to fibrillar tau pathology in Alzheimer's disease.

This study investigates blood–brain barrier (BBB) leakage in individuals with schizophrenia-spectrum disorders (SZS) compared to healthy controls using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).

This study investigates how alpha-synuclein co-pathology influences amyloid-β–induced tau aggregation, revealing that αSyn co-pathology accelerates tau accumulation and cognitive decline in Alzheimer's disease.

This study examines how female sex influences the relationship between soluble TREM2 (sTREM2) and cerebrospinal fluid phosphorylated tau (CSF p-tau) in Alzheimer's disease, suggesting that women may experience a stronger association between sTREM2-related microglial activation and tau pathology.

This study investigates how amyloid-β–induced neuronal hyperconnectivity facilitates the spread of tau pathology across connected brain regions in Alzheimer's disease.

This study examines the spatial patterns of amyloid-β and tau deposition in Vietnam War veterans with a history of traumatic brain injury (TBI), revealing distinct deposition patterns compared to typical Alzheimer's disease cases.

AAIC 2024 conference abstract, published in the Alzheimer's & Dementia supplement.

AAIC 2024 conference abstract, published in the Alzheimer's & Dementia supplement.

AAIC 2024 conference abstract, published in the Alzheimer's & Dementia supplement.

AAIC 2024 conference abstract, published in the Alzheimer's & Dementia supplement.

This study explores the relationship between neuroinflammation and tau pathology in primary 4-repeat tauopathies using PET imaging.

This study investigates the link between subcortical tau and hypoperfusion in connected cortical regions in 4-repeat tauopathies.

This paper investigates the neurobiological mechanisms underlying the effects of exercise and cognitive-behavioral interventions on fatigue in patients with rheumatoid arthritis, using magnetic resonance imaging (MRI).

This paper investigates the association between elevated cerebrospinal fluid (CSF) GAP-43 levels and the accelerated accumulation and spread of tau pathology in Alzheimer's disease.

This paper examines the effects of cerebrovascular disease on tau progression and cognitive decline in Alzheimer's disease.

This paper investigates how APOE4 facilitates the accumulation and connectivity-mediated spreading of tau pathology at lower amyloid levels.

This paper investigates the association between increased CSF GAP-43 and accelerated tau accumulation and spread in Alzheimer's disease.

This paper investigates the effect of local versus remote Beta-Amyloid on functional connectivity mediated Tau-Spread in Alzheimer's Disease.

This paper introduces ADPrep, a fully automated preprocessing pipeline for Alzheimer's disease neuroimaging analysis using MRI and multi-tracer PET data.

This paper explores the role of ApoE4 in the connectivity-mediated spreading of tau pathology at lower amyloid levels in the brain.

This paper discusses the development of a biomarker of depression using white-box machine learning of resting-state functional magnetic resonance imaging.

This paper explores the use of artificial intelligence in discovering biomarkers for Alzheimer’s disease and other forms of dementia.

This paper discusses the application of artificial intelligence in optimizing research methods for dementia studies.

This preliminary case-control study investigates whether the temporal organization of speech is associated with the volume of brain regions involved in overt sentence reading and explores the discriminative ability of temporal speech parameters and standard volumetric MRI measures for the classification of MCI and Alzheimer's disease.

This paper reports an automated approach to the clinical monitoring of Parkinson's disease (PD) by applying Evolutionary Algorithms (EAs) to resting-state functional magnetic imaging (rs-fMRI) data.

This study examines whether temporal characteristics in a collaborative referencing task are associated with cognitive function and the volumes of brain regions involved in speech production and known to be reduced in mild cognitive impairment and Alzheimer's pathology. We also explored the discriminative ability of the temporal speech measures for the classification of mild cognitive impairement and Alzheimer's disease.

This paper develops automatic methods for detecting brain imaging preclinical biomarkers for olfactory dysfunction in early stage Parkinson's disease (PD) by considering the novel application of evolutionary algorithms. Classification will be applied to PD patients with severe hyposmia, patients with no/mild hyposmia, and healthy controls.