Dr. Amir Dehsarvi

Dr. Amir Dehsarvi

I am the Principal Scientist of Neuroimaging at Boehringer Ingelheim. My research focuses on the application of machine learning and deep learning to medical data, with a strong emphasis on leveraging neuroimaging to accelerate disease diagnosis and therapeutic target identification.

Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease

Published in Brain, 2025

This study explores the relationship between fibrillar tau pathology and white matter degeneration in Alzheimer’s disease. The findings suggest that tau accumulation in the cortex is linked to lower white matter volume and faster white matter volume loss in connected regions, indicating a unidirectional relationship where cortical tau promotes atrophy in adjacent white matter.

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Recommended citation: Pescoller, J., Dewenter, A., Dehsarvi, A., Steward, A., Frontzkowski, L., Zhu, Z., Roemer-Cassiano, S.N., Palleis, C., et al. (2025). Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease. Brain. https://doi.org/10.1093/brain/awaf339

Recommended citation: Pescoller, J., Dewenter, A., Dehsarvi, A., Steward, A., Frontzkowski, L., Zhu, Z., Roemer-Cassiano, S.N., Palleis, C., et al. (2025). Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer's disease. Brain. https://doi.org/10.1093/brain/awaf339
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