Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer's disease
Published in EMBO Molecular Medicine, vol 17, issue 2., 2025
Recommended citation: Biel, D., Suárez-Calvet, M., Dewenter, A., Steward, A., Roemer, S.N., Dehsarvi, A., Zhu, Z., Pescoller, J., Frontzkowski, L., Kreuzer, A., Haass, C., Schöll, M., Brendel, M., Franzmeier, N. (2025). Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer's disease. EMBO Mol Med. 17(2): 235-248. doi: 10.1038/s44321-024-00190-3. https://doi.org/10.1038/s44321-024-00190-3
This study examines how female sex influences the relationship between soluble TREM2 (sTREM2) and cerebrospinal fluid phosphorylated tau (CSF p-tau) in Alzheimer’s disease. The findings suggest that women may experience a stronger association between sTREM2-related microglial activation and tau pathology, highlighting the need for sex-specific considerations in therapeutic strategies.
Recommended citation: Biel, D., Suárez-Calvet, M., Dewenter, A., Steward, A., Roemer, S.N., Dehsarvi, A., Zhu, Z., Pescoller, J., Frontzkowski, L., Kreuzer, A., Haass, C., Schöll, M., Brendel, M., Franzmeier, N. (2025). Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer’s disease. EMBO Mol Med. 17(2): 235-248. doi: 10.1038/s44321-024-00190-3.