Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer's disease

Published in EMBO Molecular Medicine, vol 17, issue 2., 2025

This study examines how female sex influences the relationship between soluble TREM2 (sTREM2) and cerebrospinal fluid phosphorylated tau (CSF p-tau) in Alzheimer’s disease. The findings suggest that women may experience a stronger association between sTREM2-related microglial activation and tau pathology, highlighting the need for sex-specific considerations in therapeutic strategies.

Download paper here

Recommended citation: Biel, D., Suárez-Calvet, M., Dewenter, A., Steward, A., Roemer, S.N., Dehsarvi, A., Zhu, Z., Pescoller, J., Frontzkowski, L., Kreuzer, A., Haass, C., Schöll, M., Brendel, M., Franzmeier, N. (2025). Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer’s disease. EMBO Mol Med. 17(2): 235-248. doi: 10.1038/s44321-024-00190-3.

Recommended citation: Biel, D., Suárez-Calvet, M., Dewenter, A., Steward, A., Roemer, S.N., Dehsarvi, A., Zhu, Z., Pescoller, J., Frontzkowski, L., Kreuzer, A., Haass, C., Schöll, M., Brendel, M., Franzmeier, N. (2025). Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer's disease. EMBO Mol Med. 17(2): 235-248. doi: 10.1038/s44321-024-00190-3.
Download Paper