Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer's disease
Published in Science Translational Medicine, vol 17, issue 782., 2025
Recommended citation: Roemer-Cassiano, S.N., Wagner, F., Evangelista, L., Rauchmann, B.-S., Dehsarvi, A., Steward, A., Dewenter, A., Biel, D., Zhu, Z., Pescoller, J., Gross, M., Perneczky, R., Malpetti, M., Ewers, M., Schöll, M., Dichgans, M., Höglinger, G.U., Brendel, M., Jäkel, S., Franzmeier, N. (2025). Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer's disease. Sci Transl Med. 17(782): eadp2564. doi: 10.1126/scitranslmed.adp2564. https://doi.org/10.1126/scitranslmed.adp2564
This study investigates how amyloid-β–induced neuronal hyperconnectivity facilitates the spread of tau pathology across connected brain regions in Alzheimer’s disease. The findings suggest that targeting Aβ-related neuronal hyperconnectivity may attenuate tau spreading in AD.
Recommended citation: Roemer-Cassiano, S.N., Wagner, F., Evangelista, L., Rauchmann, B.-S., Dehsarvi, A., Steward, A., Dewenter, A., Biel, D., Zhu, Z., Pescoller, J., Gross, M., Perneczky, R., Malpetti, M., Ewers, M., Schöll, M., Dichgans, M., Höglinger, G.U., Brendel, M., Jäkel, S., Franzmeier, N. (2025). Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer’s disease. Sci Transl Med. 17(782): eadp2564. doi: 10.1126/scitranslmed.adp2564.