Developing a novel reference region for [18F]PI-2620-PET imaging to facilitate the assessment of 4-repeat tauopathies
Published in European Journal of Nuclear Medicine and Molecular Imaging, 2025
This study focuses on developing a novel and optimized reference region for [18F]PI-2620-PET imaging, crucial for the accurate assessment of 4-repeat (4R) tauopathies like Progressive Supranuclear Palsy (PSP). By employing a bias-free image-derived input function (IDIF) PET quantification, the researchers identified a data-driven temporo-orbital white matter region. This new reference significantly improved the assessment of [18F]PI-2620 signal in PSP-associated regions, outperforming conventional cerebellar references and showing better diagnostic accuracy and association with clinical disease severity. The findings present a critical advancement for the diagnosis, monitoring, and treatment evaluation in 4R tauopathies.
Recommended citation: Frontzkowski, L., Gnörich, J., Gross, M., Dehsarvi, A., Roemer-Cassiano, S. N., Palleis, C., Katzdobler, S., Dewenter, A., Steward, A., Biel, D., Hirsch, F., Zhu, Z., Levin, J., Stephens, A. W., Müller, A., Koglin, N., Bischof, G. N., Kovacs, G. G., Höglinger, G. U., Brendel, M., & Franzmeier, N. (2025). Developing a novel reference region for [18F]PI-2620-PET imaging to facilitate the assessment of 4-repeat tauopathies. European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-025-07396-8
Recommended citation: Frontzkowski, L., Gnörich, J., Gross, M., Dehsarvi, A., Roemer-Cassiano, S. N., Palleis, C., Katzdobler, S., Dewenter, A., Steward, A., Biel, D., Hirsch, F., Zhu, Z., Levin, J., Stephens, A. W., Müller, A., Koglin, N., Bischof, G. N., Kovacs, G. G., Höglinger, G. U., Brendel, M., & Franzmeier, N. (2025). Developing a novel reference region for [18F]PI-2620-PET imaging to facilitate the assessment of 4-repeat tauopathies. European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-025-07396-8
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