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A list of all the posts and pages found on the site. For you robots out there, there is an XML version available for digesting as well.
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publications
Classification of resting-state fMRI for olfactory dysfunction in Parkinson's disease using evolutionary algorithms.
Published in Proceedings of the Genetic and Evolutionary Computation Conference Companion on - GECCO '18, 2018
This paper develops automatic methods for detecting brain imaging preclinical biomarkers for olfactory dysfunction in early stage Parkinson's disease (PD) by considering the novel application of evolutionary algorithms. Classification will be applied to PD patients with severe hyposmia, patients with no/mild hyposmia, and healthy controls.
Recommended citation: Dehsarvi, A., & Smith, S. L. (2018). "Classification of resting-state fMRI for olfactory dysfunction in Parkinson's disease using evolutionary algorithms." Proceedings of the Genetic and Evolutionary Computation Conference Companion on - GECCO '18. New York, New York, USA: ACM Press.
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Cognitive and structural correlates of conversational speech timing in Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's Disease: relevance for early detection approaches.
Published in Frontiers in Aging Neuroscience, 2021
This study examines whether temporal characteristics in a collaborative referencing task are associated with cognitive function and the volumes of brain regions involved in speech production and known to be reduced in mild cognitive impairment and Alzheimer's pathology. We also explored the discriminative ability of the temporal speech measures for the classification of mild cognitive impairement and Alzheimer's disease.
Recommended citation: De Looze, C., Dehsarvi, A., Crosby, L., Vourdanou, A., Coen, R. F., Lawlor, B., & Reilly, R. B. (2021). "Cognitive and structural correlates of conversational speech timing in Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's Disease: relevance for early detection approaches."; Frontiers in Aging Neuroscience. 13:637404. doi: 10.3389/fnagi.2021.637404.
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Towards Automated Monitoring of Parkinson's Disease Following Drug Treatment
Published in Pattern Recognition and Artificial Intelligence. ICPRAI 2022. Lecture Notes in Computer Science, vol 13364. Springer, Cham., 2022
This paper reports an automated approach to the clinical monitoring of Parkinson's disease (PD) by applying Evolutionary Algorithms (EAs) to resting-state functional magnetic imaging (rs-fMRI) data.
Recommended citation: Dehsarvi, A., South Palomares, J.K., Smith, S.L. (2022). Towards Automated Monitoring of Parkinson's Disease Following Drug Treatment. In: El Yacoubi, M., Granger, E., Yuen, P.C., Pal, U., Vincent, N. (eds) Pattern Recognition and Artificial Intelligence. ICPRAI 2022. Lecture Notes in Computer Science, vol 13364. Springer, Cham. doi: 10.1007/978-3-031-09282-4_17.
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Structural Correlates of Overt Sentence Reading in Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's Disease
Published in Current Alzheimer Research, 2022
This preliminary case-control study investigates whether the temporal organization of speech is associated with the volume of brain regions involved in overt sentence reading and explores the discriminative ability of temporal speech parameters and standard volumetric MRI measures for the classification of MCI and Alzheimer's disease.
Recommended citation: De Looze, C., Dehsarvi, A., Crosby, L., Vourdanou, A., Coen, R. F., Lawlor, B., & Reilly, R. B. (2022). "Structural Correlates of Overt Sentence Reading in Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's Disease"; Current Alzheimer Research. 19. doi: 10.2174/1567205019666220805110248.
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Artificial Intelligence for Dementia Research Methods Optimization
Published in Alzheimer's & Dementia, vol 19, issue 12., 2023
This paper discusses the application of artificial intelligence in optimizing research methods for dementia studies.
Recommended citation: Bucholc, M., James, C., Khleifat, A.A., Badhwar, A., Clarke, N., Dehsarvi, A., Madan, C.R., Marzi, S.J., Shand, C., Schilder, B.M., Tamburin, S., Tantiangco, H.M., Deep Dementia Phenotyping (DEMON) Network, Lourida, I., Llewellyn, D.J., Ranson, J.M. (2023). Artificial Intelligence for Dementia Research Methods Optimization. Alzheimers Dement. 19(12): 5934-5951. doi: 10.1002/alz.13441.
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Artificial Intelligence for Biomarker Discovery in Alzheimer's Disease and Dementia
Published in Alzheimer's & Dementia, vol 19, issue 12., 2023
This paper explores the use of artificial intelligence in discovering biomarkers for Alzheimer’s disease and other forms of dementia.
Recommended citation: Winchester, L.M., Harshfield, E.L., Shi, L., Badhwar, A., Khleifat, A.A., Clarke, N., Dehsarvi, A., Lengyel, I., Lourida, I., Madan, C.R., Marzi, S.J., Proitsi, P., Rajkumar, A.P., Rittman, T., Silajdžić, E., Tamburin, S., Ranson, J.M., Llewellyn, D.J. (2023). Artificial Intelligence for Biomarker Discovery in Alzheimer's Disease and Dementia. Alzheimers Dement. 19(12): 5860-5871. doi: 10.1002/alz.13390.
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Developing a Biomarker of Depression Using White-Box Machine Learning of Resting-State Functional Magnetic Resonance Imaging
Published in Neuroscience Applied, 2023
This paper discusses the development of a biomarker of depression using white-box machine learning of resting-state functional magnetic resonance imaging.
Recommended citation: Matthews, F., Dehsarvi, A., Dutta, A., Moriarty, A., Paton, L., & Smith, S. (2023). Developing a Biomarker of Depression Using White-Box Machine Learning of Resting-State Functional Magnetic Resonance Imaging. Neuroscience Applied, 2, 103668. https://doi.org/10.1016/j.neappl.2023.103668.
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ApoE4 and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels
Published in JAMA Neurology, vol 80, issue 12., 2023
This paper explores the role of ApoE4 in the connectivity-mediated spreading of tau pathology at lower amyloid levels in the brain.
Recommended citation: Steward, A., Biel, D., Dewenter, A., Roemer, S., Wagner, F., Dehsarvi, A., Rathore, S., Otero Svaldi, D., Higgins, I., Brendel, M., Dichgans, M., Shcherbinin, S., Ewers, M., Franzmeier, N. (2023). ApoE4 and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels. JAMA Neurol. 80(12): 1295-1306. doi: 10.1001/jamaneurol.2023.4038.
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ADPrep - A Fully Automated Alzheimer's Disease Neuroimaging Preprocessing Pipeline for MRI and Multi-tracer PET Data
Published in Alzheimer's & Dementia, 2023
This paper introduces ADPrep, a fully automated preprocessing pipeline for Alzheimer's disease neuroimaging analysis using MRI and multi-tracer PET data.
Recommended citation: Dehsarvi, A., Denecke, J., Biel, D., Dewenter, A., Roemer, S.N., Steward, A., Wanger, F., Brendel, M., Franzmeier, N. (2023). ADPrep - A fully automated Alzheimer's Disease Neuroimaging Preprocessing Pipeline for MRI and multi-tracer PET data. Alzheimer's Dement., 19: e079614. https://doi.org/10.1002/alz.079614.
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The Effect of Local versus Remote Beta-Amyloid on Functional Connectivity Mediated Tau-Spread in Alzheimer's Disease
Published in Alzheimer's & Dementia, 2023
This paper investigates the effect of local versus remote Beta-Amyloid on functional connectivity mediated Tau-Spread in Alzheimer's Disease.
Recommended citation: Wanger, F., Steward, A., Biel, D., Dewenter, A., Roemer, S.N., Ewers, M., Dehsarvi, A., Franzmeier, N. (2023). The Effect of Local versus Remote Beta-Amyloid on Functional Connectivity Mediated Tau-Spread in Alzheimer's Disease. Alzheimer's Dement., 19: e079578. https://doi.org/10.1002/alz.079578.
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Increased CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer's disease
Published in Alzheimer's & Dementia, 2023
This paper investigates the association between increased CSF GAP-43 and accelerated tau accumulation and spread in Alzheimer's disease.
Recommended citation: Franzmeier, N., Dehsarvi, A., Steward, A., Biel, D., Dewenter, A., Roemer, S.N., Wanger, F., Brendel, M., Ewers, M., Moscoso, A., Blennow, K., Zetterberg, H., Schoell, M. (2023). Increased CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer's disease. Alzheimer's Dement., 19: e080039. https://doi.org/10.1002/alz.080039.
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APOE4 Facilitates the Accumulation and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels
Published in Alzheimer's & Dementia, 2023
This paper investigates how APOE4 facilitates the accumulation and connectivity-mediated spreading of tau pathology at lower amyloid levels.
Recommended citation: Steward, A., Biel, D., Dewenter, A., Roemer, S.N., Wanger, F., Dehsarvi, A., Svaldi, D., Higgins, I.A., Brendel, M., Shcherbinin, S., Ewers, M., Franzmeier, N. (2023). APOE4 Facilitates the Accumulation and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels. Alzheimer's Dement., 19: e074017. https://doi.org/10.1002/alz.074017.
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Effects of Cerebrovascular Disease on Tau Progression and Cognitive Decline in Alzheimer's Disease
Published in Alzheimer's & Dementia, 2023
This paper examines the effects of cerebrovascular disease on tau progression and cognitive decline in Alzheimer's disease.
Recommended citation: Dewenter, A., Steward, A., Dehsarvi, A., Biel, D., Roemer, S.N., Wanger, F., Franzmeier, N. (2023). Effects of Cerebrovascular Disease on Tau Progression and Cognitive Decline in Alzheimer's Disease. Alzheimer's Dement., 19: e078894. https://doi.org/10.1002/alz.078894.
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Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer's disease
Published in Nature Communications, vol 15, issue 1., 2024
This paper investigates the association between elevated cerebrospinal fluid (CSF) GAP-43 levels and the accelerated accumulation and spread of tau pathology in Alzheimer's disease.
Recommended citation: Franzmeier, N., Dehsarvi, A., Steward, A., Biel, D., Dewenter, A., Roemer, S.N., Wagner, F., Gross, M., Brendel, M., Moscoso, A., Arunachalam, P., Blennow, K., Zetterberg, H., Ewers, M., Schoell, M. (2024). Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer's disease. Nat Commun. 15(1): 202. doi: 10.1038/s41467-023-44374-w.
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Characterizing the Neurobiological Mechanisms of Action of Exercise and Cognitive-Behavioral Interventions for Rheumatoid Arthritis Fatigue: A Magnetic Resonance Imaging Brain Study
Published in Arthritis & Rheumatology, vol 76, issue 4., 2024
This paper investigates the neurobiological mechanisms underlying the effects of exercise and cognitive-behavioral interventions on fatigue in patients with rheumatoid arthritis, using magnetic resonance imaging (MRI).
Recommended citation: Dehsarvi, A., Al-Wasity, S., Stefanov, K., Wiseman, S.J., Ralston, S.H., Wardlaw, J.M., Emsley, R., Bachmair, E.M., Cavanagh, J., Waiter, G.D., Basu, N. (2024). Characterizing the Neurobiological Mechanisms of Action of Exercise and Cognitive-Behavioral Interventions for Rheumatoid Arthritis Fatigue: A Magnetic Resonance Imaging Brain Study. Arthritis Rheumatol. 76(4): 522-530. doi: 10.1002/art.42755.
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Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies
Published in Brain, 2024; awae174., 2024
This study investigates the link between subcortical tau and hypoperfusion in connected cortical regions in 4-repeat tauopathies.
Recommended citation: Roemer, S.N., Brendel, M., Gnoerich, J., Malpetti, M., Zaganjori, M., Quattrone, A., Gross, M., Steward, A., Dewenter, A., Wagner, F., Dehsarvi, A., Ferschmann, C., Wall, S., Palleis, C., Rauchmann, B.S., Katzdobler, S., Jaeck, A., Stockbauer, A., Fietzek, U.M., Bernhardt, A.M., Weidinger, E., Zwergal, A., Stoecklein, S., Perneczky, R., Barthel, H., Sabri, O., Levin, J., Hoeglinger, G.U., Franzmeier, N. (2024). Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies. Brain, 2024; awae174. doi: 10.1093/brain/awae174.
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Neuroinflammation Parallels 18F-PI-2620 Positron Emission Tomography Patterns in Primary 4-Repeat Tauopathies
Published in Movement Disorders, 2024
This study explores the relationship between neuroinflammation and tau pathology in primary 4-repeat tauopathies using PET imaging.
Recommended citation: Malpetti, M., Roemer, S.N., Harris, S., Gross, M., Gnörich, J., Stephens, A., Dewenter, A., Steward, A., Biel, D., Dehsarvi, A., Wagner, F., Müller, A., Koglin, N., Weidinger, E., Palleis, C., Katzdobler, S., Rupprecht, R., Perneczky, R., Rauchmann, B.-S., Levin, J., Höglinger, G.U., Brendel, M., Franzmeier, N. (2024). Neuroinflammation Parallels 18F-PI-2620 Positron Emission Tomography Patterns in Primary 4-Repeat Tauopathies. Movement Disorders. doi: 10.1002/mds.29924.
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Amyloid-β and tau deposition in traumatic brain injury: a study of Vietnam War veterans
Published in Brain Communications, vol 7, issue 1., 2025
This study examines the spatial patterns of amyloid-β and tau deposition in Vietnam War veterans with a history of traumatic brain injury (TBI), revealing distinct deposition patterns compared to typical Alzheimer's disease cases.
Recommended citation: de Bruin, H., Groot, C., Kamps, S., Vijverberg, E.G.B., Steward, A., Dehsarvi, A., Pijnenburg, Y.A.L., Ossenkoppele, R., Franzmeier, N. (2025). Amyloid-β and tau deposition in traumatic brain injury: a study of Vietnam War veterans. Brain Commun. 7(1): fcaf009. doi: 10.1093/braincomms/fcaf009.
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Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer's disease
Published in Science Translational Medicine, vol 17, issue 782., 2025
This study investigates how amyloid-β–induced neuronal hyperconnectivity facilitates the spread of tau pathology across connected brain regions in Alzheimer's disease.
Recommended citation: Roemer-Cassiano, S.N., Wagner, F., Evangelista, L., Rauchmann, B.-S., Dehsarvi, A., Steward, A., Dewenter, A., Biel, D., Zhu, Z., Pescoller, J., Gross, M., Perneczky, R., Malpetti, M., Ewers, M., Schöll, M., Dichgans, M., Höglinger, G.U., Brendel, M., Jäkel, S., Franzmeier, N. (2025). Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer's disease. Sci Transl Med. 17(782): eadp2564. doi: 10.1126/scitranslmed.adp2564.
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Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer's disease
Published in EMBO Molecular Medicine, vol 17, issue 2., 2025
This study examines how female sex influences the relationship between soluble TREM2 (sTREM2) and cerebrospinal fluid phosphorylated tau (CSF p-tau) in Alzheimer's disease, suggesting that women may experience a stronger association between sTREM2-related microglial activation and tau pathology.
Recommended citation: Biel, D., Suárez-Calvet, M., Dewenter, A., Steward, A., Roemer, S.N., Dehsarvi, A., Zhu, Z., Pescoller, J., Frontzkowski, L., Kreuzer, A., Haass, C., Schöll, M., Brendel, M., Franzmeier, N. (2025). Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer's disease. EMBO Mol Med. 17(2): 235-248. doi: 10.1038/s44321-024-00190-3.
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Alpha-synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer's disease
Published in Molecular Neurodegeneration, vol 20, article number 31., 2025
This study investigates how alpha-synuclein co-pathology influences amyloid-β–induced tau aggregation, revealing that αSyn co-pathology accelerates tau accumulation and cognitive decline in Alzheimer's disease.
Recommended citation: Franzmeier, N., Roemer-Cassiano, S.N., Bernhardt, A.M., Dehsarvi, A., Dewenter, A., Steward, A., Biel, D., Frontzkowski, L., Zhu, Z., Gnörich, J., Pescoller, J., Wagner, F., Hirsch, F., de Bruin, H., Ossenkoppele, R., Palleis, C., Strübing, F., Schöll, M., Levin, J., Brendel, M., Höglinger, G.U. (2025). Alpha-synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer's disease. Mol Neurodegener. 20(31). doi: 10.1186/s13024-025-00822-3.
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Higher blood–brain barrier leakage in schizophrenia-spectrum disorders: A comparative dynamic contrast-enhanced magnetic resonance imaging study with healthy controls
Published in Brain, Behavior, and Immunity, vol 128, pp 40-49., 2025
This study investigates blood–brain barrier (BBB) leakage in individuals with schizophrenia-spectrum disorders (SZS) compared to healthy controls using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).
Recommended citation: Moussiopoulou, J., Yakimov, V., Roell, L., Rauchmann, B.-S., Toth, H., Melcher, J., Jäger, I., Lutz, I., Kallweit, M. S., Papazov, B., Boudriot, E., Seelos, K., Dehsarvi, A., Campana, M., Raabe, F., Maurus, I., Lührs, L., Brendel, M., Stöcklein, S., Falkai, P., Hasan, A., CDP Working Group, Franzmeier, N., Keeser, D., & Wagner, E. (2025). Higher blood–brain barrier leakage in schizophrenia-spectrum disorders: A comparative dynamic contrast-enhanced magnetic resonance imaging study with healthy controls. Brain, Behavior, and Immunity, 128, 40-49. https://doi.org/10.1016/j.bbi.2025.04.003
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talks
The Application of Evolutionary Algorithms for the Analysis of Brain Imaging Data
Published:
I talked about my work on how artificial intelligence can be used for the analysis of medical data with the aim of exploring novel and superior techniques for diagnosis and treatment of different diseases, including rheumatoid arthritis, Alzheimer's disease, and Parkinson's disease.
The Application of Evolutionary Algorithms for the Analysis of Biomedical Data
Published:
I talked about my work on how I have used different machine learning techniques for the analysis of biomedical data in order to identify different approaches and methods to help with the diagnosis and treatment of different diseases, including chronic diseases with fatigue as a symptom, and neurodegenerative diseases, such as Alzheimer's disease, and Parkinson's disease.
The Application of Evolutionary Algorithms for the Analysis of Biomedical Data
Published:
I talked about how Evolutionary Algorithms can be used for identifying biomarkers in different modalities to help with the diagnosis and treatment of different diseases, including rheumatoid arthritis, Alzheimer's disease, and Parkinson's disease.
Towards Automated Monitoring of Parkinson's Disease Following Drug Treatment
Published:
I talked about an automated approach to the clinical monitoring of Parkinson's disease (PD) by applying Evolutionary Algorithms (EAs) to resting-state functional magnetic imaging (rs-fMRI) data. The novel application of EAs to both map and predict the functional connectivity is considered in patients receiving the drug Modafinil versus placebo.
teaching
Lab Leader and Postgraduate Teaching Assistant
Workshop, University of York, Department of Electronic Engineering, 2017
Teaching, demonstrating, and marking for undergraduate and postgraduate students, Department of Electronic Engineering. BSc and MSc modules include: Electronics for Medicine, Maths and C Programming, Digital & Analogue Electronics Labs, Computer Architecture Workshops, Electronics for Music Technology, among others.
SINAPSE/MathWorks MATLAB for Image Processing Training course
Programming Course, SINAPSE Image Analysis Research Group, 2021
I am the programme leader for the 2021 SINAPSE-IA/MathWorks MATLAB for Image Processing course, teaching advanced MATLAB (including Machine learning, deep learning, SPM, etc.) targeted at Universities across Scotland (a cohort of 40 researchers from postgraduate to professorship level).