Alpha-synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer's disease
Published in Molecular Neurodegeneration, vol 20, article number 31., 2025
This study investigates how alpha-synuclein co-pathology influences amyloid-β–induced tau aggregation, revealing that αSyn co-pathology accelerates tau accumulation and cognitive decline in Alzheimer's disease.
Recommended citation: Franzmeier, N., Roemer-Cassiano, S.N., Bernhardt, A.M., Dehsarvi, A., Dewenter, A., Steward, A., Biel, D., Frontzkowski, L., Zhu, Z., Gnörich, J., Pescoller, J., Wagner, F., Hirsch, F., de Bruin, H., Ossenkoppele, R., Palleis, C., Strübing, F., Schöll, M., Levin, J., Brendel, M., Höglinger, G.U. (2025). Alpha-synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer's disease. Mol Neurodegener. 20(31). doi: 10.1186/s13024-025-00822-3. https://doi.org/10.1186/s13024-025-00822-3